Psicofarmacología Integradora en la Era de la Neurociencia: Fundamentos Teóricos para una Nueva Generación de Intervenciones en Salud Mental

Jose Santos-Morocho

doi:10.70171/m4sgq770

Authors

Jose Santos-Morocho Universidad UTE Author https://orcid.org/0000-0001-8824-6344

DOI:

https://doi.org/10.70171/m4sgq770

Keywords:

psychopharmacology, psychotropic drugs, neurotransmission, mental disorders, pharmacological treatment

Abstract

Justification: Population aging and structural conditions of vulnerability are associated with situations of poverty, dependency, and limited support networks among the older adult population, factors that affect psychosocial well-being and the processes of strengthening resilience in institutional contexts. Objective: To analyze the theoretical, neurobiological, and historical foundations of psychopharmacology and its relevance in the clinical approach to psychopathologies. Methodology: A theoretical approach with an analytical-synthetic method was used. The information was obtained through a bibliographic and documentary review of scientific articles, academic books, and indexed sources, under a non-experimental descriptive-analytical design. Results: The review shows that psychotropic drugs act on brain neurotransmission systems, modulating neural circuits associated with mood, cognition, and behavior. Likewise, advances in neuroscience, pharmacodynamics, pharmacokinetics, and pharmacogenomics have led to the development of more effective and personalized treatments. Conclusion: Psychopharmacology is a fundamental pillar of modern psychiatry, integrating knowledge from neuroscience and clinical practice to improve the understanding and treatment of mental disorders.

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References

Allen, L. V., Popovich, N. G., & Ansel, H. C. (2020). Ansel's pharmaceutical dosage forms and drug delivery systems (11th ed.). Wolters Kluwer.

Aulton, M. E., & Taylor, K. (2018). Aulton's pharmaceutics: The design and manufacture of medicines (5th ed.). Elsevier.

Baldessarini, R. J. (2013). Chemotherapy in psychiatry: Pharmacologic basis of treatments for major mental illness (3rd ed.). Springer.

Ban, T. A. (1996). An introduction to the history of psychopharmacology. In T. A. Ban, N. S. Sartorius, & C. Ban (Eds.), Psychopharmacology and the history of psychiatry (pp. 1–20). International Network for the History of Neuropsychopharmacology.

Ban, T. A. (1999). Psychopharmacology and the classification of psychiatric disorders. International Network for the History of Neuropsychopharmacology.

Ban, T. A. (2001). Pharmacotherapy of mental illness: A historical analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 25(4), 709–727.

Bandelow, B., Michaelis, S., & Wedekind, D. (2017). Treatment of anxiety disorders. Dialogues in Clinical Neuroscience, 19(2), 93–107. https://doi.org/10.31887/DCNS.2017.19.2/bbandelow

Barlow, D. H., Durand, V. M., & Hofmann, S. G. (2021). Abnormal psychology: An integrative approach (9th ed.). Cengage Learning.

Bear, M. F., Connors, B. W., & Paradiso, M. A. (2020). Neuroscience: Exploring the brain (4th ed.). Wolters Kluwer.

Benedetti, F. (2014). Placebo effects: Understanding the mechanisms in health and disease (2nd ed.). Oxford University Press.

Brunton, L. L., Hilal-Dandan, R., & Knollmann, B. C. (2018). Goodman & Gilman's: The pharmacological basis of therapeutics (13th ed.). McGraw-Hill Education.

Carlson, N. R., & Birkett, M. A. (2021). Physiology of behavior (13th ed.). Pearson.

Colom, F., & Vieta, E. (2006). Psychoeducation manual for bipolar disorder. Cambridge University Press.

Cuijpers, P., Noma, H., Karyotaki, E., Cipriani, A., & Furukawa, T. A. (2020). Effectiveness and acceptability of cognitive behavior therapy delivery formats in adults with depression: A network meta-analysis. JAMA Psychiatry, 77(7), 700–707. https://doi.org/10.1001/jamapsychiatry.2019.0268

DiMatteo, M. R. (2004). Variations in patients' adherence to medical recommendations. Medical Care, 42(3), 200–209. https://doi.org/10.1097/01.mlr.0000114908.90348.f9

Edwards, I. R., & Aronson, J. K. (2000). Adverse drug reactions: Definitions, diagnosis, and management. The Lancet, 356(9237), 1255–1259. https://doi.org/10.1016/S0140-6736(00)02799-9

Healy, D. (2002). The creation of psychopharmacology. Harvard University Press.

Hopkins, A. L. (2008). Network pharmacology: The next paradigm in drug discovery. Nature Chemical Biology, 4(11), 682–690. https://doi.org/10.1038/nchembio.118

Kaplan, H. I., & Sadock, B. J. (2015). Kaplan & Sadock's synopsis of psychiatry: Behavioral sciences/clinical psychiatry (11th ed.). Wolters Kluwer.

Katzung, B. G. (2021). Basic and clinical pharmacology (15th ed.). McGraw-Hill Education.

Kazdin, A. E. (2021). Research design in clinical psychology (5th ed.). Cambridge University Press.

López-Muñoz, F., & Alamo, C. (2009). Historical evolution of psychopharmacology. Journal of Clinical Psychopharmacology, 29(6), 555–564.

López-Muñoz, F., Alamo, C., & Cuenca, E. (2011). The discovery of chlorpromazine and the introduction of neuroleptics in psychiatry. Annals of Clinical Psychiatry, 23(4), 292–301.

Meyer, J. S., & Quenzer, L. F. (2004). Psychopharmacology: Drugs, the brain, and behavior. Sinauer Associates.

Meyer, J. S., & Quenzer, L. F. (2019). Psychopharmacology: Drugs, the brain, and behavior (3rd ed.). Sinauer Associates.

Moreau de Tours, J. J. (1845). Du hachisch et de l’aliénation mentale: Études psychologiques. Paris: Masson.

Morrison, V., & Bennett, P. (2020). An introduction to health psychology (4th ed.). Pearson.

Nestler, E. J., Hyman, S. E., & Malenka, R. C. (2015). Molecular neuropharmacology: A foundation for clinical neuroscience (3rd ed.). McGraw-Hill.

Nestler, E. J., Hyman, S. E., & Malenka, R. C. (2022). Molecular neuropharmacology: A foundation for clinical neuroscience (4th ed.). McGraw-Hill.

Pérez-Rincón, H. (1990). La psicofarmacología. Salud Mental, 13(1), 1-7.

Pérez-Rincón, H. (1990). Moreau de Tours and the origins of psychopharmacology. Journal of the History of the Neurosciences, 1(3), 203–210.

Rang, H. P., Ritter, J. M., Flower, R. J., & Henderson, G. (2019). Rang & Dale's pharmacology (9th ed.). Elsevier.

Rowland, M., & Tozer, T. N. (2011). Clinical pharmacokinetics and pharmacodynamics: Concepts and applications (4th ed.). Lippincott Williams & Wilkins.

Sadock, B. J., Sadock, V. A., & Ruiz, P. (2021). Kaplan & Sadock's synopsis of psychiatry (12th ed.). Wolters Kluwer.

Schatzberg, A. F., & Nemeroff, C. B. (2017). The American psychiatric association publishing textbook of psychopharmacology (5th ed.). American Psychiatric Association Publishing.

Shorter, E. (1997). A history of psychiatry: From the era of the asylum to the age of Prozac. John Wiley & Sons.

Sneader, W. (2005). Drug discovery: A history. John Wiley & Sons.

Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.

Stahl, S. M. (2021). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (5th ed.). Cambridge University Press.

Taylor, S. E. (2018). Health psychology (10th ed.). McGraw-Hill.

WHO Collaborating Centre for Drug Statistics Methodology. (2022). ATC/DDD index. Norwegian Institute of Public Health.

World Health Organization. (2002). Safety of medicines: A guide to detecting and reporting adverse drug reactions. WHO.

World Health Organization. (2023). International nonproprietary names (INN) for pharmaceutical substances. WHO.

Zohar, J., Stahl, S., Moller, H. J., Blier, P., Kupfer, D., Yamawaki, S., ... & Nutt, D. (2015). A review of the current nomenclature for psychotropic agents and an introduction to the neuroscience-based nomenclature. European Neuropsychopharmacology, 25(12), 2318–2325.